What the FDA labels say about taking them together
Insulin lispro and somatropin
Insulin lispro's FDA label of June 4, 2025 names somatropin in its drug interactions section; somatropin's label does not name insulin lispro itself but warns about its class (insulin analogs). The insulin lispro label: “… niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, and thyroid hormones. …”
Check it at the source: the insulin lispro FDA label on DailyMed (effective June 4, 2025, Sanofi-Aventis U.S. LLC); the somatropin FDA label on DailyMed (effective August 20, 2026, Eli Lilly and Company).
What does the insulin lispro label say about somatropin?
Insulin lispro label, drug interactionsDrugs That May Decrease the Blood Glucose Lowering Effect of ADMELOG Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. Intervention: Dose adjustment and increased frequency of glucose monitoring may be required when ADMELOG is concomitantly administered with these drugs.
Source: FDA drug label (Lyumjev, BLA761109), Eli Lilly and Company, effective June 16, 2026 (SPL set c5a056e2-b568-4ca6-9ed8-79c010942d00), via openFDA
Source: FDA drug label (Insulin Lispro, BLA020563), Eli Lilly and Company, effective June 17, 2025 (SPL set 97d5e596-aae1-42c9-ae89-c3780959c467), via openFDA
Source: FDA drug label (Humalog Mix75/25, BLA021017), Eli Lilly and Company, effective June 16, 2026 (SPL set c73da51a-1899-45ad-b6cf-9c52c36a25dd), via openFDA
Source: FDA drug label (ADMELOG), Sanofi-Aventis U.S. LLC, effective June 4, 2025 (SPL set 0691def8-4a7b-4de3-866f-a280989f47f1), via openFDA; the full label on DailyMed
What does the somatropin label say about insulin lispro?
Somatropin's label does not name insulin lispro itself; it warns about its class (insulin analogs):
Somatropin label, drug interactionsInsulin and/or Other Hypoglycemic Agents
Somatropin label, drug interactionsTreatment with HUMATROPE may decrease insulin sensitivity, particularly at higher doses.
Source: FDA drug label (HUMATROPE), Eli Lilly and Company, effective August 20, 2026 (SPL set a774e1ae-3997-49ee-8b0e-99a2b315d409), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Insulin lispro | Somatropin | |
|---|---|---|
| Labeled for | Type 2 diabetes, Type 1 diabetes | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $10.19 per mL 100 unit/mL kwikpen | $752.22 per cartridge 5 mg cartridge |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once