What the FDA labels say about taking them together
Clozapine and insulin lispro
Insulin lispro's FDA label of June 4, 2025 names clozapine in its drug interactions section; the clozapine labels PlainMeds reads (2) do not name insulin lispro. The insulin lispro label: “Drugs That May Decrease the Blood Glucose Lowering Effect of Insulin Lispro Drugs: Atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives …”
Check it at the source: the clozapine FDA label on DailyMed (effective June 6, 2025, HLS Therapeutics (USA), Inc.); the insulin lispro FDA label on DailyMed (effective June 4, 2025, Sanofi-Aventis U.S. LLC).
What does the clozapine label say about insulin lispro?
Clozapine's label (effective June 6, 2025) and its 1 other brand-application label do not name insulin lispro in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clozaril), NDA019758 (Heritage Life), as published by HLS Therapeutics (USA), Inc., effective June 6, 2025 (SPL set 90876802-0e3a-44c9-9ff7-1754dfbe736a), via openFDA; the full label on DailyMed
What does the insulin lispro label say about clozapine?
Insulin lispro label, drug interactionsDrugs That May Decrease the Blood Glucose Lowering Effect of ADMELOG Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. Intervention: Dose adjustment and increased frequency of glucose monitoring may be required when ADMELOG is concomitantly administered with these drugs.
Source: FDA drug label (Lyumjev, BLA761109), Eli Lilly and Company, effective June 16, 2026 (SPL set c5a056e2-b568-4ca6-9ed8-79c010942d00), via openFDA
Source: FDA drug label (Insulin Lispro, BLA020563), Eli Lilly and Company, effective June 17, 2025 (SPL set 97d5e596-aae1-42c9-ae89-c3780959c467), via openFDA
Source: FDA drug label (Humalog Mix75/25, BLA021017), Eli Lilly and Company, effective June 16, 2026 (SPL set c73da51a-1899-45ad-b6cf-9c52c36a25dd), via openFDA
Source: FDA drug label (ADMELOG), Sanofi-Aventis U.S. LLC, effective June 4, 2025 (SPL set 0691def8-4a7b-4de3-866f-a280989f47f1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clozapine | Insulin lispro | |
|---|---|---|
| Labeled for | Schizophrenia | Type 2 diabetes, Type 1 diabetes |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.610 per tablet 100 mg tablet | $10.19 per mL 100 unit/mL kwikpen |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once