What the FDA labels say about taking them together
Clonidine and insulin lispro
Insulin lispro's FDA label of June 4, 2025 names clonidine in its drug interactions section; the clonidine labels PlainMeds reads (4) do not name insulin lispro. The insulin lispro label: “Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of ADMELOG Drugs: Alcohol, beta-blockers, clonidine, and lithium salts.”
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the insulin lispro FDA label on DailyMed (effective June 4, 2025, Sanofi-Aventis U.S. LLC).
What does the clonidine label say about insulin lispro?
Clonidine's label (effective March 30, 2026) and its 3 other brand-application labels do not name insulin lispro in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the insulin lispro label say about clonidine?
Insulin lispro label, drug interactionsDrugs That May Increase or Decrease the Blood Glucose Lowering Effect of ADMELOG Drugs: Alcohol, beta-blockers, clonidine, and lithium salts.
Source: FDA drug label (Lyumjev, BLA761109), Eli Lilly and Company, effective June 16, 2026 (SPL set c5a056e2-b568-4ca6-9ed8-79c010942d00), via openFDA
Source: FDA drug label (Insulin Lispro, BLA020563), Eli Lilly and Company, effective June 17, 2025 (SPL set 97d5e596-aae1-42c9-ae89-c3780959c467), via openFDA
Source: FDA drug label (Humalog Mix75/25, BLA021017), Eli Lilly and Company, effective June 16, 2026 (SPL set c73da51a-1899-45ad-b6cf-9c52c36a25dd), via openFDA
Source: FDA drug label (ADMELOG), Sanofi-Aventis U.S. LLC, effective June 4, 2025 (SPL set 0691def8-4a7b-4de3-866f-a280989f47f1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Insulin lispro | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Type 2 diabetes, Type 1 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $10.19 per mL 100 unit/mL kwikpen |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once