Insulin Glargine and Lithium Interaction
Drug interaction information between Insulin Glargine and Lithium.
Insulin Glargine and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Glargine and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lithium can interfere with how your body handles sugar, causing your blood sugar levels to fluctuate up or down.
FDA Label Information
Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of BASAGLAR Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine ( 7 ).
Insulin Glargine Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Insulin Glargine + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Insulin Glargine's 11. In the minor band specifically: Insulin Glargine has 8 (also Albuterol, Clonidine, Olanzapine, Clozapine); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Insulin Glargine and Lithium?
Lithium can interfere with how your body handles sugar, causing your blood sugar levels to fluctuate up or down.
Lithium carries more major-labeled pairs than Insulin Glargine
SPL source-record counts only. This page's band is minor · classes on file: Insulin Glargine (Long-Acting Insulin); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Insulin Glargine's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 8 minor · 11 total
- Other minor peers for Insulin Glargine
- Albuterol
- Clonidine
- Olanzapine
- Clozapine
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.