Insulin Glargine and Clozapine Interaction
Drug interaction information between Insulin Glargine and Clozapine.
Insulin Glargine and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Glargine and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clozapine can make it harder for insulin to lower your blood sugar, potentially leading to high blood sugar levels.
FDA Label Information
Drugs That May Decrease the Blood Glucose Lowering Effect of BASAGLAR Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones Intervention: Dose increases and increased frequency of glucose monitoring may be required when BASAGLAR is co-administered with these drugs.
Insulin Glargine Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Glargine + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Insulin Glargine's 11. In the minor band specifically: Insulin Glargine has 8 (also Albuterol, Clonidine, Olanzapine, Lithium); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Insulin Glargine and Clozapine?
Clozapine can make it harder for insulin to lower your blood sugar, potentially leading to high blood sugar levels.
Clozapine's labeled portfolio outnumbers Insulin Glargine
SPL source-record counts only. This page's band is minor · classes on file: Insulin Glargine (Long-Acting Insulin); Clozapine (Atypical Antipsychotic).
0 major · 3 moderate · 8 minor · 11 total
- Other minor peers for Insulin Glargine
- Albuterol
- Clonidine
- Olanzapine
- Lithium
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.