What the FDA labels say about taking them together
Insulin detemir and octreotide
Insulin detemir's FDA label of October 9, 2024 names octreotide in its drug interactions section; octreotide's label does not name insulin detemir itself but warns about its class (insulin analogs). The insulin detemir label: “… inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors. …”
Check it at the source: the insulin detemir FDA label on DailyMed (effective October 9, 2024); the octreotide FDA label on DailyMed (effective July 22, 2026, Novartis Pharmaceuticals Corporation).
What does the insulin detemir label say about octreotide?
Insulin detemir label, drug interactionsDrugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors. Intervention: Dosage reductions and increased frequency of glucose monitoring may be required when LEVEMIR is co-administered with these drugs.
Source: FDA drug label (Levemir), A-S Medication Solutions, effective October 9, 2024 (SPL set 82192527-99aa-4b53-8ce9-9173668d309c), via openFDA; the full label on DailyMed
What does the octreotide label say about insulin detemir?
Octreotide's label does not name insulin detemir itself; it warns about its class (insulin analogs):
Octreotide label, drug interactionsCyclosporine, insulin, oral hypoglycemic agents, beta-blockers, and bromocriptine. ( 7 ) Lutetium Lu 177
Octreotide label, drug interactionsOctreotide inhibits the secretion of insulin and glucagon.
Source: FDA drug label (Sandostatin), Novartis Pharmaceuticals Corporation, effective July 22, 2026 (SPL set 4e2c9856-1836-49f0-9472-4dbeeb408f39), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Insulin detemir | Octreotide | |
|---|---|---|
| Labeled for | Type 2 diabetes, Type 1 diabetes | Diarrhea |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $2.53 per mL 100 mcg/mL vial |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once