Insulin Detemir and Clonidine Interaction
Drug interaction information between Insulin Detemir and Clonidine.
Insulin Detemir and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Detemir and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clonidine can make blood sugar levels unpredictable and can also hide the physical warning signs of low blood sugar.
FDA Label Information
Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of LEVEMIR Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs That May Blunt Signs and Symptoms of Hypoglycemia Drugs: Beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when LEVEMIR is co-administered with these drugs. ( 7 ) • Antiadrenergic Drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine): Signs and symptoms of hypoglycemia may be reduced or absent.
Insulin Detemir Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Olanzapine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Detemir + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Insulin Detemir's 11. In the minor band specifically: Insulin Detemir has 8 (also Albuterol, Olanzapine, Lithium, Clozapine); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Insulin Detemir and Clonidine?
Clonidine can make blood sugar levels unpredictable and can also hide the physical warning signs of low blood sugar.
Clonidine's labeled portfolio outnumbers Insulin Detemir
SPL source-record counts only. This page's band is minor · classes on file: Insulin Detemir (Long-Acting Insulin); Clonidine (Central Alpha-2 Agonist).
0 major · 3 moderate · 8 minor · 11 total
- Other minor peers for Insulin Detemir
- Albuterol
- Olanzapine
- Lithium
- Clozapine
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.