Insulin Detemir and Fluoxetine Interaction
Drug interaction information between Insulin Detemir and Fluoxetine.
Insulin Detemir and Fluoxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Detemir and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can interfere with how your body manages sugar, which increases the risk of your blood sugar falling too low while on insulin.
Insulin Detemir Also Interacts With
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Insulin Detemir + Fluoxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Insulin Detemir's 11. In the moderate band specifically: Insulin Detemir has 3 (also Pramlintide, Octreotide); Fluoxetine has 19 (also Alprazolam, Diazepam, Carbamazepine, Haloperidol).
What mechanism field is on file for Insulin Detemir and Fluoxetine?
Fluoxetine can interfere with how your body manages sugar, which increases the risk of your blood sugar falling too low while on insulin.
Fluoxetine carries more major-labeled pairs than Insulin Detemir
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Detemir (Long-Acting Insulin); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Insulin Detemir's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 8 minor · 11 total
- Other moderate peers for Insulin Detemir
- Pramlintide
- Octreotide
6 major · 19 moderate · 43 minor · 68 total
- Other moderate peers for Fluoxetine
- Alprazolam
- Diazepam
- Carbamazepine
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.