Insulin Degludec and Clozapine Interaction
Drug interaction information between Insulin Degludec and Clozapine.
Insulin Degludec and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Degludec and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clozapine can make insulin less effective, which may cause your blood sugar to stay too high.
FDA Label Information
Drugs That May Decrease the Blood Glucose Lowering Effect of XULTOPHY 100/3.6 Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Insulin Degludec Also Interacts With
- Fluoxetine moderate
- Liraglutide moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Degludec + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Insulin Degludec's 12. In the minor band specifically: Insulin Degludec has 8 (also Albuterol, Clonidine, Olanzapine, Lithium); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Insulin Degludec and Clozapine?
Clozapine can make insulin less effective, which may cause your blood sugar to stay too high.
Clozapine's labeled portfolio outnumbers Insulin Degludec
SPL source-record counts only. This page's band is minor · classes on file: Insulin Degludec (Ultra-Long-Acting Insulin); Clozapine (Atypical Antipsychotic).
0 major · 4 moderate · 8 minor · 12 total
- Other minor peers for Insulin Degludec
- Albuterol
- Clonidine
- Olanzapine
- Lithium
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.