What the FDA labels say about taking them together
Insulin aspart and protamine
Insulin aspart's FDA label (Insulin Aspart Protamine And Insulin Aspart Mix 70/30) of February 28, 2023 names protamine in its contraindications section; protamine's label does not name insulin aspart itself but warns about its class (insulin analogs). The insulin aspart label: “CONTRAINDICATIONS Insulin Aspart Protamine and Insulin Aspart Mix 70/30 is contraindicated:”
Check it at the source: the insulin aspart FDA label on DailyMed (effective June 21, 2023, Novo Nordisk); the protamine FDA label on DailyMed (effective April 29, 2025, Fresenius Kabi USA, LLC).
What does the insulin aspart label say about protamine?
Insulin Aspart Protamine And Insulin Aspart Mix 70/30 label (Novo Nordisk Pharma, Inc., February 28, 2023), contraindicationsCONTRAINDICATIONS Insulin Aspart Protamine and Insulin Aspart Mix 70/30 is contraindicated:
Insulin Aspart Protamine And Insulin Aspart Mix 70/30 label (Novo Nordisk Pharma, Inc., February 28, 2023), drug interactionsDRUG INTERACTIONS The table below presents clinically significant drug interactions with Insulin Aspart Protamine and Insulin Aspart Mix 70/30 Table 3:
Insulin Aspart Protamine And Insulin Aspart Mix 70/30 label (Novo Nordisk Pharma, Inc., February 28, 2023), warnings and precautionsDiscontinue Insulin Aspart Protamine and Insulin Aspart Mix 70/30, treat, and monitor, if indicated (5.5).
Source: FDA drug label (Insulin Aspart Protamine And Insulin Aspart Mix 70/30, BLA021172), Novo Nordisk Pharma, Inc., effective February 28, 2023 (SPL set fc94baa4-3606-48bc-a781-9617ab6960ef), via openFDA
Source: FDA drug label (Fiasp), Novo Nordisk, effective June 21, 2023 (SPL set 834e7efc-393f-4c55-9125-628562a8a5cf), via openFDA; the full label on DailyMed
What does the protamine label say about insulin aspart?
Protamine's label does not name insulin aspart itself; it warns about its class (insulin analogs):
Protamine label, boxed warningRisk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers).
Source: FDA drug label (Protamine Sulfate), Fresenius Kabi USA, LLC, effective April 29, 2025 (SPL set c76876da-b9a8-45d0-9278-7df3288d3a06), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Insulin aspart | Protamine | |
|---|---|---|
| Labeled for | Type 2 diabetes, Type 1 diabetes | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $6.95 per mL 100 unit/mL vial | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once