What the FDA labels say about taking them together
Indapamide and lithium
Indapamide's FDA label of October 1, 2022 names lithium in its warnings section; the lithium labels PlainMeds reads (4) do not name indapamide. The indapamide label: “In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity.”
Check it at the source: the indapamide FDA label on DailyMed (effective October 1, 2022, Actavis Pharma, Inc.); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the indapamide label say about lithium?
Indapamide label, warningsIn general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity.
Source: FDA drug label (Indapamide), Actavis Pharma, Inc., effective October 1, 2022 (SPL set a8a4ec2c-9d4b-482b-ad29-88185c96db74), via openFDA; the full label on DailyMed
What does the lithium label say about indapamide?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name indapamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indapamide | Lithium | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure, Edema (fluid retention) | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.109 per tablet 1.25 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once