Imipenem/Cilastatin and Probenecid Interaction
Drug interaction information between Imipenem/Cilastatin and Probenecid.
Imipenem/Cilastatin and Probenecid have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Imipenem/Cilastatin and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid keeps imipenem in your blood for a longer time and at higher levels than usual.
FDA Label Information
Probenecid: Concomitant administration of PRIMAXIN and probenecid results in increases in the plasma level and half-life of imipenem. 7.2 Probenecid Concomitant administration of PRIMAXIN and probenecid results in increases in the plasma level and half-life of imipenem. Therefore, it is not recommended that probenecid be given concomitantly with PRIMAXIN.
Imipenem/Cilastatin Also Interacts With
- Ganciclovir minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Imipenem/Cilastatin + Probenecid?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Imipenem/Cilastatin's 2. In the moderate band specifically: Imipenem/Cilastatin has 1; Probenecid has 12 (also Amoxicillin, Amoxicillin/Clavulanate, Ceftazidime/Avibactam, Cefuroxime).
What mechanism field is on file for Imipenem/Cilastatin and Probenecid?
Probenecid keeps imipenem in your blood for a longer time and at higher levels than usual.
Probenecid carries more major-labeled pairs than Imipenem/Cilastatin
SPL source-record counts only. This page's band is moderate · classes on file: Imipenem/Cilastatin (Carbapenem Antibiotic Combination); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Imipenem/Cilastatin's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 1 minor · 2 total
Imipenem/Cilastatin has no other moderate-band peer in this dataset besides Probenecid.
2 major · 12 moderate · 23 minor · 37 total
- Other moderate peers for Probenecid
- Amoxicillin
- Amoxicillin/Clavulanate
- Ceftazidime/Avibactam
- Cefuroxime
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.