What the FDA labels say about taking them together
Iloperidone and milsaperidone
Milsaperidone's FDA label of February 27, 2026 names iloperidone in its drug interactions section; the iloperidone label PlainMeds reads does not name milsaperidone. The milsaperidone label: “Strong CYP2D6 inhibitors increased exposure of milsaperidone and iloperidone, which may increase the risk of BYSANTI-associated adverse reactions.”
Check it at the source: the iloperidone FDA label on DailyMed (effective May 6, 2026, Vanda Pharmaceuticals Inc.); the milsaperidone FDA label on DailyMed (effective February 27, 2026, Vanda Pharmaceuticals Inc.).
What does the iloperidone label say about milsaperidone?
Iloperidone's label (effective May 6, 2026) does not name milsaperidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (FANAPT), Vanda Pharmaceuticals Inc., effective May 6, 2026 (SPL set 33f60b40-3fca-11de-8f56-0002a5d5c51b), via openFDA; the full label on DailyMed
What does the milsaperidone label say about iloperidone?
Milsaperidone label, drug interactionsStrong CYP2D6 inhibitors increased exposure of milsaperidone and iloperidone [see Clinical Pharmacology (12.3, 12.5) ], which may increase the risk of BYSANTI-associated adverse reactions.
Milsaperidone label, warnings and precautionsIn a QTc study, the use of iloperidone (iloperidone and milsaperidone rapidly interconvert in vivo) was associated with QTc interval prolongation, especially with concomitant use of a CYP2D6 inhibitor or a CYP3A4 inhibitor.
Source: FDA drug label (BYSANTI), Vanda Pharmaceuticals Inc., effective February 27, 2026 (SPL set 254a1c01-4a4c-4bdd-85d6-1f23f2e4e6f8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Iloperidone | Milsaperidone | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder | Schizophrenia, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $60.01 per tablet 12 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once