What the FDA labels say about taking them together
Iloperidone and ketoconazole
Iloperidone's FDA label of May 6, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name iloperidone. The iloperidone label: “The effect of FANAPT on the QT interval was augmented by the presence of CYP450 2D6 or 3A4 metabolic inhibition.”
Check it at the source: the iloperidone FDA label on DailyMed (effective May 6, 2026, Vanda Pharmaceuticals Inc.); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the iloperidone label say about ketoconazole?
Iloperidone label, drug interactionsClinical Impact; Co-administration of ketoconazole with iloperidone, increased the AUC of iloperidone and its metabolites P88 and P95 by 57%, 55%, and 35%, respectively [see ].
Iloperidone label, warnings and precautionsThe effect of FANAPT on the QT interval was augmented by the presence of CYP450 2D6 or 3A4 metabolic inhibition (paroxetine 20 mg once daily and ketoconazole 200 mg twice daily, respectively).
Source: FDA drug label (FANAPT), Vanda Pharmaceuticals Inc., effective May 6, 2026 (SPL set 33f60b40-3fca-11de-8f56-0002a5d5c51b), via openFDA; the full label on DailyMed
What does the ketoconazole label say about iloperidone?
Ketoconazole's label (effective January 28, 2026) does not name iloperidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Iloperidone | Ketoconazole | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $60.01 per tablet 12 mg tablet | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once