What the FDA labels say about taking them together
Hydroxyzine and levocetirizine
Hydroxyzine's FDA label of March 3, 2026 names levocetirizine in its contraindications section; the levocetirizine labels PlainMeds reads (2) do not name hydroxyzine. The hydroxyzine label: “… and in patients with known hypersensitivity to cetirizine hydrochloride or levocetirizine hydrochloride.”
Check it at the source: the hydroxyzine FDA label on DailyMed (effective March 3, 2026, Aurobindo Pharma Limited); the levocetirizine FDA label on DailyMed (effective March 11, 2026, Chattem, Inc.).
What does the hydroxyzine label say about levocetirizine?
Hydroxyzine label, contraindicationsCONTRAINDICATIONS Oral hydroxyzine hydrochloride is contraindicated in patients with known hypersensitivity to hydroxyzine hydrochloride products, and in patients with known hypersensitivity to cetirizine hydrochloride or levocetirizine hydrochloride.
Source: FDA drug label (Hydroxyzine Hydrochloride), Aurobindo Pharma Limited, effective March 3, 2026 (SPL set 9de2de56-614f-4294-8794-d30758cf5f70), via openFDA; the full label on DailyMed
What does the levocetirizine label say about hydroxyzine?
Levocetirizine's label (effective March 11, 2026) and its 1 other brand-application label do not name hydroxyzine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xyzal Allergy 24HR), Chattem, Inc., effective March 11, 2026 (SPL set 8be45c2a-1eca-4a00-81b9-f7babdbdcd41), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydroxyzine | Levocetirizine | |
|---|---|---|
| Labeled for | Anxiety, Alcohol use disorder | Allergies |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0326 per tablet 25 mg tablet | $0.0511 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once