Over-the-counter medication · Second-Generation Antihistamine
levocetirizine
Also sold as Xyzal. This medicine treats allergy symptoms.
Data updated 2026-05-15
- $0.15
- Generic price (NADAC)
levocetirizine (Xyzal) is an over-the-counter Second-Generation Antihistamine. This medicine treats allergy symptoms.
Levocetirizine is an antihistamine medicine. It helps relieve allergy symptoms.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.15/unit
Generic Available
Yes (14 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
NADAC price trail: LEVOCETIRIZINE 2.5 MG/5 ML SOL
Same CMS presentation as the headline generic unit price above (2 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: +15.6% vs prior release.
| Effective | NADAC / unit | vs prior | NDCs |
|---|---|---|---|
| October 23, 2024 | $0.1772/ML | - | 1 |
| December 18, 2024 | $0.2048/ML | +15.6% | 4 |
What it does
This medicine treats allergy symptoms.
Common side effects
No common side effects listed.
Key warnings
If you have kidney disease, do not use this medicine.
The sections below are summarized in plain English from levocetirizine's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Levocetirizine blocks histamine, a natural substance your body makes during an allergic reaction. By blocking histamine, it reduces allergy symptoms.
Serious Warnings
If you have kidney disease, do not use this medicine. Children under 6 years of age should not use this medicine.
Common Questions
Can I take more than one tablet a day?
What should I do if my symptoms don't improve?
Can children under 6 take this medicine?
Can I take this medicine if I have kidney problems?
When is the best time to take this medicine?
Can I drive or operate machinery after taking this medicine?
Can I drink alcohol while taking this medicine?
Is there a generic version of this medicine?
How long does it take for this medicine to work?
Can I take this medicine with other allergy medicines?
What drug class is levocetirizine?
What pregnancy or breastfeeding source fields are listed for levocetirizine?
Related Medications in Second-Generation Antihistamine
Other drugs grouped near levocetirizine - same-class peers and common alternatives.
azelastine
Astelin, Astepro
Azelastine nasal spray is an antihistamine medicine.
Compare with levocetirizine →
budesonide nasal
Rhinocort
Rhinocort is a nasal spray that helps relieve allergy symptoms.
Compare with levocetirizine →
cetirizine
Zyrtec
Cetirizine (Zyrtec) is an antihistamine medicine.
Compare with levocetirizine →
chlorpheniramine
Chlor-Trimeton
Chlorpheniramine is an antihistamine medicine.
Compare with levocetirizine →
ciclesonide nasal
Omnaris, Zetonna
Omnaris Nasal Spray is a medicine that helps treat allergy symptoms in your nose.
Compare with levocetirizine →
Medication Guides
Understanding Drug Interactions
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Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
What the FDA Data Shows for levocetirizine
The FDA label for levocetirizine (sold under brand names such as Xyzal) classifies it as an over-the-counter product in the Second-Generation Antihistamine class. This medicine treats allergy symptoms. Labeling covers dosing, contraindications, and monitoring requirements derived from clinical trials.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS shows a generic unit cost of $0.15.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: December 10, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages