What the FDA labels say about taking them together
Hydrocortisone and warfarin
Hydrocortisone's FDA label (Solu-Cortef) of August 27, 2026 names warfarin in its drug interactions section; warfarin's label does not name hydrocortisone itself but warns about its class (Corticosteroids).
Check it at the source: the hydrocortisone FDA label on DailyMed (effective August 19, 2026); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the hydrocortisone label say about warfarin?
Solu-Cortef label (Pharmacia & Upjohn Company LLC, August 27, 2026), drug interactionsAnticoagulants, oral: Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports.
Alkindi Sprinkle label (Eton Pharmaceuticals, Inc., April 21, 2026), drug interactionsAnticoagulant Agents Clinical Impact: Concomitant use of warfarin and corticosteroids usually results in inhibition of response to warfarin, although there have been some conflicting reports. Intervention: Monitor coagulation indices in patients receiving ALKINDI SPRINKLE and concomitant warfarin to maintain the desired anticoagulant effect.
Source: FDA drug label (Solu-Cortef, NDA009866), Pharmacia & Upjohn Company LLC, effective August 27, 2026 (SPL set 65eefd58-b166-4d71-ade6-45c8fdf86922), via openFDA
Source: FDA drug label (Alkindi Sprinkle, NDA213876), Eton Pharmaceuticals, Inc., effective April 21, 2026 (SPL set 26c13a5f-7119-4c6a-bf10-fda4e07d7682), via openFDA
Source: FDA drug label (hydrocortisone 1), Kroger Company, effective August 19, 2026 (SPL set f05edff2-2dc5-427c-b52c-518e0aaef4e0), via openFDA; the full label on DailyMed
What does the warfarin label say about hydrocortisone?
Warfarin's label does not name hydrocortisone itself; it warns about its class (Corticosteroids):
Warfarin label, drug interactionsMore frequent INR monitoring should be performed when starting or stopping other drugs, including botanicals, or when changing dosages of other drugs, including drugs intended for short-term use (e.g., antibiotics, antifungals, corticosteroids) [see Boxed Warning ].
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydrocortisone | Warfarin | |
|---|---|---|
| Labeled for | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis) | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0613 per gram 1% cream | $0.093 per tablet 2 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once