Hydrochlorothiazide and Aliskiren Interaction
Drug interaction information between Hydrochlorothiazide and Aliskiren.
Hydrochlorothiazide and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Hydrochlorothiazide and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together can put too much stress on your kidneys and cause your blood pressure to drop to unsafe levels.
FDA Label Information
Dual Blockade of the Renin-Angiotensin System (RAS): Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or direct renin inhibitors (such as aliskiren) is associated with increased risk of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with lisinopril and hydrochlorothiazide tablets in patients with diabetes. Avoid use of aliskiren with PRINZIDE in patients with renal impairment (GFR <60 ml/min).
Hydrochlorothiazide Also Interacts With
- Hydrochlorothiazide major
- Lisinopril minor
- Losartan minor
- Spironolactone minor
- Propranolol minor
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Triamterene + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Hydrochlorothiazide's 13. In the major band specifically: Hydrochlorothiazide has 2 (also Hydrochlorothiazide); Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Hydrochlorothiazide/Triamterene and Aliskiren?
Using these two drugs together can put too much stress on your kidneys and cause your blood pressure to drop to unsafe levels.
Aliskiren carries more major-labeled pairs than Hydrochlorothiazide
SPL source-record counts only. This page's band is major · classes on file: Hydrochlorothiazide (Thiazide / Potassium-Sparing Diuretic Combination); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Hydrochlorothiazide's 2.
2 major · 0 moderate · 11 minor · 13 total
- Other major peers for Hydrochlorothiazide
- Hydrochlorothiazide
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.