What the FDA labels say about taking them together
Eplerenone and hydrochlorothiazide/lisinopril
Hydrochlorothiazide/lisinopril's FDA label of March 31, 2025 names eplerenone in its drug interactions section; eplerenone's label does not name hydrochlorothiazide/lisinopril itself but warns about its class (ACE inhibitors, Thiazide diuretics). The hydrochlorothiazide/lisinopril label: “Use of lisinopril with potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.”
Check it at the source: the eplerenone FDA label on DailyMed (effective June 23, 2025, Viatris Specialty LLC); the hydrochlorothiazide/lisinopril FDA label on DailyMed (effective March 31, 2025, Almatica Pharma Inc.).
What does the eplerenone label say about hydrochlorothiazide/lisinopril?
Eplerenone's label does not name hydrochlorothiazide/lisinopril itself; it warns about its class (ACE inhibitors, Thiazide diuretics):
Eplerenone label, drug interactionsInhibitors and Angiotensin II Receptor Antagonists The risk of hyperkalemia increases when eplerenone is used in combination with an ACE inhibitor and/or an ARB.
Eplerenone label, drug interactionsLithium toxicity has been reported in patients receiving lithium concomitantly with diuretics and ACE inhibitors.
Source: FDA drug label (Inspra), NDA021437 (Upjohn), as published by Viatris Specialty LLC, effective June 23, 2025 (SPL set 1a52bedc-8e2c-4116-a296-a87770676b4a), via openFDA; the full label on DailyMed
What does the hydrochlorothiazide/lisinopril label say about eplerenone?
Hydrochlorothiazide/lisinopril label, drug interactionsUse of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Source: FDA drug label (Zestoretic), Almatica Pharma Inc., effective March 31, 2025 (SPL set 0d3a966f-f937-05a8-a90f-5aa52ebbd613), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eplerenone | Hydrochlorothiazide/lisinopril | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | High blood pressure |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.308 per tablet 25 mg tablet | $0.0293 per tablet 10-12.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once