What the FDA labels say about taking them together
Histamine and propranolol
Histamine's FDA label of November 3, 2025 names propranolol in its drug interactions (prescription label) section; the propranolol labels PlainMeds reads (4) do not name histamine. The histamine label: “Beta Blocking Agents: Propranolol can significantly increase skin test reactivity, including histamine.”
Check it at the source: the histamine FDA label on DailyMed (effective November 3, 2025); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the histamine label say about propranolol?
Histamine label, drug interactions (prescription label)Beta Blocking Agents: Propranolol can significantly increase skin test reactivity, including histamine.
Source: FDA drug label (Histaminum hydrochloricum), Boiron, effective November 3, 2025 (SPL set 85b905d4-5fa3-7125-e053-2a91aa0a54f4), via openFDA; the full label on DailyMed
What does the propranolol label say about histamine?
Propranolol's label (effective January 15, 2026) and its 3 other brand-application labels do not name histamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Histamine | Propranolol | |
|---|---|---|
| Labeled for | n/a | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once