What the FDA labels say about taking them together
Heparin and sertraline
Sertraline's FDA label of August 8, 2023 names heparin in its drug interactions section; the heparin labels PlainMeds reads (4) do not name sertraline. The sertraline label: “The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding.”
Check it at the source: the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the heparin label say about sertraline?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name sertraline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
What does the sertraline label say about heparin?
Sertraline label, drug interactionsDrugs that Interfere with Hemostasis (antiplatelet agents and anticoagulants) Clinical Impact: The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding. Intervention: Inform patients of the increased risk of bleeding associated with the concomitant use of ZOLOFT and antiplatelet agents and anticoagulants. For patients taking warfarin, carefully monitor the international normalized ratio [See ]. Examples: aspirin, clopidogrel, heparin, warfarin
Source: FDA drug label (Sertraline Hydrochloride, NDA020990), Mylan Pharmaceuticals Inc., effective September 15, 2024 (SPL set 1a58062b-e635-431a-908d-2651c6a4a21c), via openFDA
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Heparin | Sertraline | |
|---|---|---|
| Labeled for | Blood clots (DVT and PE), Atrial fibrillation | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.18 per mL 5,000 unit/mL vial | $0.0507 per tablet 100 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once