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What the FDA labels say about taking them together

Granisetron and ketoconazole

Granisetron's FDA label of August 31, 2017 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name granisetron.

Check it at the source: the granisetron FDA label on DailyMed (effective August 31, 2017, Mylan Institutional LLC); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).

What does the granisetron label say about ketoconazole?

Granisetron label, drug interactions

In in vitro human microsomal studies, ketoconazole inhibited ring oxidation of granisetron hydrochloride.

Source: FDA drug label (Granisetron Hydrochloride), Mylan Institutional LLC, effective August 31, 2017 (SPL set 8d88adba-7f5e-4e97-84b3-6ca8ec98c023), via openFDA; the full label on DailyMed

What does the ketoconazole label say about granisetron?

Ketoconazole's label (effective January 28, 2026) does not name granisetron in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

8Granisetron generic labelers
30Ketoconazole generic labelers
GranisetronKetoconazole
Labeled forNausea and vomitingFungal infections
Boxed warningNoNo
Pharmacy cost (NADAC)$1.31 per tablet 1 mg tablet$0.249 per gram 2% cream
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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