What the FDA labels say about taking them together
Glycopyrrolate and propofol
Propofol's FDA label of September 11, 2025 names glycopyrrolate in its warnings and precautions section; the glycopyrrolate labels PlainMeds reads (4) do not name propofol. The propofol label: “The intravenous administration of anticholinergic agents should be considered to modify potential increases in vagal tone due to concomitant agents (e.g., succinylcholine) or surgical stimuli.”
Check it at the source: the glycopyrrolate FDA label on DailyMed (effective October 9, 2025, Hikma Pharmaceuticals USA Inc.); the propofol FDA label on DailyMed (effective September 11, 2025, Fresenius Kabi USA, LLC).
What does the glycopyrrolate label say about propofol?
Glycopyrrolate's label (effective October 9, 2025) and its 3 other brand-application labels do not name propofol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Glycopyrrolate), Hikma Pharmaceuticals USA Inc., effective October 9, 2025 (SPL set 960d2dd0-008d-4ec1-ba2e-9388b28b23e2), via openFDA; the full label on DailyMed
What does the propofol label say about glycopyrrolate?
Propofol label, warnings and precautionsThe intravenous administration of anticholinergic agents (e.g., atropine or glycopyrrolate) should be considered to modify potential increases in vagal tone due to concomitant agents (e.g., succinylcholine) or surgical stimuli.
Source: FDA drug label (Diprivan), Fresenius Kabi USA, LLC, effective September 11, 2025 (SPL set e3105799-a4b6-f3f4-e6e2-b2b29bbdb538), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glycopyrrolate | Propofol | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.51 per mL 0.2 mg/mL vial | $0.171 per mL 200 mg/20 mL vial |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once