Glycopyrrolate and Midazolam Interaction
Drug interaction information between Glycopyrrolate and Midazolam.
Glycopyrrolate and Midazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glycopyrrolate and Midazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not have any known harmful interactions when used together during surgery or anesthesia.
FDA Label Information
No significant adverse interactions with commonly used premedications or drugs used during anesthesia and surgery (including atropine, scopolamine, glycopyrrolate, diazepam, hydroxyzine, d-tubocurarine, succinylcholine and other nondepolarizing muscle relaxants) or topical local anesthetics (including lidocaine, dyclonine HCl and Cetacaine) have been observed in adults or pediatric patients.
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Glycopyrrolate + Midazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Midazolam has 39 labeled pairs on file vs Glycopyrrolate's 2. In the minor band specifically: Glycopyrrolate has 2 (also Potassium Chloride); Midazolam has 27 (also Hydroxyzine, Nifedipine, Morphine, Diazepam).
What mechanism field is on file for Glycopyrrolate and Midazolam?
These drugs do not have any known harmful interactions when used together during surgery or anesthesia.
Midazolam carries more major-labeled pairs than Glycopyrrolate
SPL source-record counts only. This page's band is minor · classes on file: Glycopyrrolate (Long-Acting Muscarinic Antagonist (LAMA)); Midazolam (Benzodiazepine).
Midazolam has 3 major-labeled pairs vs Glycopyrrolate's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 2 minor · 2 total
- Other minor peers for Glycopyrrolate
- Potassium Chloride
3 major · 9 moderate · 27 minor · 39 total
- Other minor peers for Midazolam
- Hydroxyzine
- Nifedipine
- Morphine
- Diazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.