What the FDA labels say about taking them together
Glycerol phenylbutyrate and probenecid
Glycerol phenylbutyrate's FDA label of October 29, 2025 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name glycerol phenylbutyrate.
Check it at the source: the glycerol phenylbutyrate FDA label on DailyMed (effective October 29, 2025, Horizon Therapeutics USA, Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the glycerol phenylbutyrate label say about probenecid?
Glycerol phenylbutyrate label, drug interactionsDrugs to Affect RAVICTI Probenecid Probenecid may inhibit the renal excretion of metabolites of RAVICTI including PAGN and PAA.
Source: FDA drug label (Ravicti), Horizon Therapeutics USA, Inc., effective October 29, 2025 (SPL set 900e7dc0-9afe-4f50-80de-90567bb78519), via openFDA; the full label on DailyMed
What does the probenecid label say about glycerol phenylbutyrate?
Probenecid's label (effective January 5, 2021) does not name glycerol phenylbutyrate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glycerol phenylbutyrate | Probenecid | |
|---|---|---|
| Labeled for | n/a | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.636 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once