What the FDA labels say about taking them together
Glyburide and probenecid
Glyburide's FDA label of July 1, 2021 names probenecid in its drug interactions section; probenecid's label does not name glyburide itself but warns about its class (Sulfonylureas).
Check it at the source: the glyburide FDA label on DailyMed (effective July 1, 2021, TEVA Pharmaceuticals USA Inc); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the glyburide label say about probenecid?
Glyburide label, drug interactionsDrug Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents.
Source: FDA drug label (Glyburide), NDA017532 (Sanofi Aventis Us), as published by TEVA Pharmaceuticals USA Inc, effective July 1, 2021 (SPL set 50d16f1d-c814-4411-8749-62561321ecce), via openFDA; the full label on DailyMed
What does the probenecid label say about glyburide?
Probenecid's label does not name glyburide itself; it warns about its class (Sulfonylureas):
Probenecid label, drug interactionsProbenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glyburide | Probenecid | |
|---|---|---|
| Labeled for | Type 2 diabetes | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0643 per tablet 5 mg tablet | $0.636 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once