What the FDA labels say about taking them together
Glimepiride and ivacaftor
Ivacaftor's FDA label of March 23, 2026 names glimepiride in its drug interactions section; the glimepiride label PlainMeds reads does not name ivacaftor. The ivacaftor label: “Other therapeutic products for which exposure may be increased by KALYDECO include glimepiride and glipizide; these therapeutic products should be used with caution.”
Check it at the source: the glimepiride FDA label on DailyMed (effective May 12, 2025, Micro Labs Limited); the ivacaftor FDA label on DailyMed (effective March 23, 2026, Vertex Pharmaceuticals Incorporated).
What does the glimepiride label say about ivacaftor?
Glimepiride's label (effective May 12, 2025) does not name ivacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Glimepiride), Micro Labs Limited, effective May 12, 2025 (SPL set 60e9397e-83b9-489e-9683-6f87e458bbaa), via openFDA; the full label on DailyMed
What does the ivacaftor label say about glimepiride?
Ivacaftor label, drug interactionsOther therapeutic products for which exposure may be increased by KALYDECO include glimepiride and glipizide; these therapeutic products should be used with caution [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Kalydeco), Vertex Pharmaceuticals Incorporated, effective March 23, 2026 (SPL set 0ab0c9f8-3eee-4e0f-9f3f-c1e16aaffe25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glimepiride | Ivacaftor | |
|---|---|---|
| Labeled for | Type 2 diabetes | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0507 per tablet 4 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once