What the FDA labels say about taking them together
Epinephrine and glimepiride
Glimepiride's FDA label of May 12, 2025 names epinephrine in its drug interactions section; the epinephrine labels PlainMeds reads (4) do not name glimepiride. The glimepiride label: “The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors …”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the glimepiride FDA label on DailyMed (effective May 12, 2025, Micro Labs Limited).
What does the epinephrine label say about glimepiride?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name glimepiride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the glimepiride label say about epinephrine?
Glimepiride label, drug interactionsThe following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid.
Source: FDA drug label (Glimepiride), Micro Labs Limited, effective May 12, 2025 (SPL set 60e9397e-83b9-489e-9683-6f87e458bbaa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Glimepiride | |
|---|---|---|
| Labeled for | Asthma | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $0.0507 per tablet 4 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once