What the FDA labels say about taking them together
Furosemide and meclofenamate
Meclofenamate's FDA label of April 15, 2026 names furosemide in its drug interactions section; the furosemide labels PlainMeds reads (4) do not name meclofenamate. The meclofenamate label: “Furosemide Clinical studies, as well as post-marketing observations, have shown that meclofenamate sodium can reduce the natriuretic effect-of furosemide and thiazides in some patients.”
Check it at the source: the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC); the meclofenamate FDA label on DailyMed (effective April 15, 2026, Mylan Pharmaceuticals Inc.).
What does the furosemide label say about meclofenamate?
Furosemide's label (effective September 30, 2025) and its 3 other brand-application labels do not name meclofenamate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
What does the meclofenamate label say about furosemide?
Meclofenamate label, drug interactionsFurosemide Clinical studies, as well as post-marketing observations, have shown that meclofenamate sodium can reduce the natriuretic effect-of furosemide and thiazides in some patients.
Source: FDA drug label (Meclofenamate Sodium), Mylan Pharmaceuticals Inc., effective April 15, 2026 (SPL set 96f19af4-de8f-4fd7-90d8-55fe6ebdd81d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Furosemide | Meclofenamate | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Fever, Pain, Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.490 per mL 20 mg/2 mL vial | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once