What the FDA labels say about taking them together
Fluvoxamine and ropivacaine
Ropivacaine's FDA label of August 6, 2024 names fluvoxamine in its drug interactions section; the fluvoxamine labels PlainMeds reads (2) do not name ropivacaine. The ropivacaine label: “In vivo, the plasma clearance of ropivacaine was reduced by 70% during coadministration of fluvoxamine (25 mg bid for 2 days), a selective and potent CYP1A2 inhibitor.”
Check it at the source: the fluvoxamine FDA label on DailyMed (effective June 27, 2026, Zydus Pharmaceuticals USA Inc.); the ropivacaine FDA label on DailyMed (effective August 6, 2024, Fresenius Kabi USA, LLC).
What does the fluvoxamine label say about ropivacaine?
Fluvoxamine's label (effective June 27, 2026) and its 1 other brand-application label do not name ropivacaine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvoxamine maleate extended-release), Zydus Pharmaceuticals USA Inc., effective June 27, 2026 (SPL set 6c71d4f6-54b5-4d3a-8d2f-b7773c92c32e), via openFDA; the full label on DailyMed
What does the ropivacaine label say about fluvoxamine?
Ropivacaine label, drug interactionsIn vivo, the plasma clearance of ropivacaine was reduced by 70% during coadministration of fluvoxamine (25 mg bid for 2 days), a selective and potent CYP1A2 inhibitor.
Source: FDA drug label (Naropin), Fresenius Kabi USA, LLC, effective August 6, 2024 (SPL set 23d2d448-a744-4877-9f2d-7e57c198da89), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvoxamine | Ropivacaine | |
|---|---|---|
| Labeled for | n/a | Pain |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $4.08 per capsule 100 mg capsule | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once