What the FDA labels say about taking them together
Fluticasone and voriconazole
Fluticasone's FDA label of December 19, 2024 names voriconazole in its drug interactions (prescription label) section; voriconazole's label does not name fluticasone itself but warns about its class (Corticosteroids). The fluticasone label: “Interactions with Strong Cytochrome P450 3A4 Inhibitors Caution should be exercised when considering the coadministration of ARNUITY ELLIPTA with ketoconazole and other known strong CYP3A4 inhibitors because increased …”
Check it at the source: the fluticasone FDA label on DailyMed (effective December 19, 2024, Haleon US Holdings LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the fluticasone label say about voriconazole?
Fluticasone label, drug interactions (prescription label)The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin, conivaptan, lopinavir, voriconazole) with XHANCE is not recommended because increased systemic corticosteroid adverse effects may occur.
Arnuity Ellipta label (GlaxoSmithKline LLC, October 18, 2023), warnings and precautionsInteractions with Strong Cytochrome P450 3A4 Inhibitors Caution should be exercised when considering the coadministration of ARNUITY ELLIPTA with ketoconazole and other known strong CYP3A4 inhibitors (including, but not limited to, ritonavir, clarithromycin, conivaptan, indinavir, itraconazole, lopinavir, nefazodone, nelfinavir, saquinavir, telithromycin, troleandomycin, voriconazole) because increased systemic corticosteroid adverse effects may occur [see Drug Interactions ( 7.1 ), Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Arnuity Ellipta, NDA205625), GlaxoSmithKline LLC, effective October 18, 2023 (SPL set 50f193ee-1691-486d-9370-a664df63695c), via openFDA
Source: FDA drug label (FLONASE ALLERGY RELIEF), Haleon US Holdings LLC, effective December 19, 2024 (SPL set b6134ba0-b70a-4eac-9a82-cef64b242c1d), via openFDA; the full label on DailyMed
What does the voriconazole label say about fluticasone?
Voriconazole's label does not name fluticasone itself; it warns about its class (Corticosteroids):
Voriconazole label, drug interactionsMonitor for potential adrenal dysfunction when VFEND is administered with other corticosteroids [see Warnings and Precautions (5.8) ].
Voriconazole label, warnings and precautionsCarefully monitor patients receiving VFEND and corticosteroids (via all routes of administration) for adrenal dysfunction both during and after VFEND treatment.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluticasone | Voriconazole | |
|---|---|---|
| Labeled for | Allergies, Asthma, Eczema (atopic dermatitis) | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.243 per gram 0.05% cream | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once