What the FDA labels say about taking them together
Fluoxetine and propranolol
Propranolol's FDA label of January 15, 2026 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name propranolol. The propranolol label: “… substrates or inhibitors of CYP2D6, such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.”
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the fluoxetine label say about propranolol?
Fluoxetine's label (effective January 8, 2026) does not name propranolol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the propranolol label say about fluoxetine?
Propranolol label, drug interactionsSubstrates or Inhibitors of CYP2D6 Blood levels and/or toxicity of propranolol may be increased by co-administration with substrates or inhibitors of CYP2D6, such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.
Inderal Xl label (ANI Pharmaceuticals, Inc., August 27, 2026), drug interactionsImpact of Other Drugs on Propranolol CYP2D6, CYP1A2 and CYP2C19 Inhibitors: CYP2D6 inhibitors (e.g. bupropion, fluoxetine, paroxetine, quinidine), CYP1A2 inhibitors (e.g., ciprofloxacin, enoxamine, fluvoxamine) and CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) increase exposure to propranolol when co-administered with INDERAL XL.
Source: FDA drug label (Inderal Xl, NDA021438), ANI Pharmaceuticals, Inc., effective August 27, 2026 (SPL set ac196ff5-9215-402b-bc57-69aa87f8bade), via openFDA
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Propranolol | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once