What the FDA labels say about taking them together
Fludrocortisone and midodrine
Midodrine's FDA label of December 4, 2025 names fludrocortisone in its drug interactions section; the fludrocortisone label PlainMeds reads does not name midodrine. The midodrine label: “The potential for supine hypertension should be carefully monitored in these patients and may be minimized by either reducing the dose of fludrocortisone acetate or decreasing the salt intake prior to initiation of …”
Check it at the source: the fludrocortisone FDA label on DailyMed (effective October 29, 2024, Zydus Lifesciences Limited); the midodrine FDA label on DailyMed (effective December 4, 2025, Novugen Pharma (USA) LLC).
What does the fludrocortisone label say about midodrine?
Fludrocortisone's label (effective October 29, 2024) does not name midodrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fludrocortisone acetate), Zydus Lifesciences Limited, effective October 29, 2024 (SPL set 6c4a7d2d-00a4-4d80-ab4c-2afd4e4f614e), via openFDA; the full label on DailyMed
What does the midodrine label say about fludrocortisone?
Midodrine label, drug interactionsThe potential for supine hypertension should be carefully monitored in these patients and may be minimized by either reducing the dose of fludrocortisone acetate or decreasing the salt intake prior to initiation of treatment with midodrine hydrochloride.
Source: FDA drug label (Midodrine Hydrochloride), Novugen Pharma (USA) LLC, effective December 4, 2025 (SPL set 2bf011fe-d114-42a4-93e2-76a993a3ba34), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fludrocortisone | Midodrine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.311 per tablet 0.1 mg tablet | $0.111 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once