What the FDA labels say about taking them together
Fludrocortisone and hydrocortisone
Fludrocortisone's FDA label of October 29, 2024 names hydrocortisone in its warnings section; the hydrocortisone labels PlainMeds reads (4) do not name fludrocortisone. The fludrocortisone label: “Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium.”
Check it at the source: the fludrocortisone FDA label on DailyMed (effective October 29, 2024, Zydus Lifesciences Limited); the hydrocortisone FDA label on DailyMed (effective August 19, 2026).
What does the fludrocortisone label say about hydrocortisone?
Fludrocortisone label, warningsAverage and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium.
Source: FDA drug label (Fludrocortisone acetate), Zydus Lifesciences Limited, effective October 29, 2024 (SPL set 6c4a7d2d-00a4-4d80-ab4c-2afd4e4f614e), via openFDA; the full label on DailyMed
What does the hydrocortisone label say about fludrocortisone?
Hydrocortisone's label (effective August 19, 2026) and its 3 other brand-application labels do not name fludrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (hydrocortisone 1), Kroger Company, effective August 19, 2026 (SPL set f05edff2-2dc5-427c-b52c-518e0aaef4e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fludrocortisone | Hydrocortisone | |
|---|---|---|
| Labeled for | n/a | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.311 per tablet 0.1 mg tablet | $0.0613 per gram 1% cream |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once