Fluconazole · more major-labeled pairs than Lemborexant
SPL labels Fluconazole + Lemborexant as moderate; Fluconazole 7 / Lemborexant 2 in that band.
Mechanism on file: Fluconazole causes a large increase in the amount of lemborexant in your body, which can make you feel dangerously sleepy.
FDA SPL severity: Moderate
Fluconazole + Lemborexant · SPL mechanism field
Fluconazole causes a large increase in the amount of lemborexant in your body, which can make you feel dangerously sleepy.
Moderate band excerpt · Fluconazole with Lemborexant
Lemborexant: Concomitant administration of fluconazole increased lemborexant C max and AUC by approximately 1.6- and 4.2-fold, respectively which is expected to increase risk of adverse reactions, such as somnolence. Avoid concomitant use of fluconazole with lemborexant.
Fluconazole · 3 major-labeled pairs (vs Lemborexant's 0)
- Amiodarone moderate
- Atorvastatin moderate
- Carbamazepine moderate
- Fluvastatin moderate
Lemborexant · 2 moderate + 11 total pairs
- Voriconazole moderate
- Bupropion minor
- Carbamazepine minor
- Chlorzoxazone minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.