What the FDA labels say about taking them together
Fluconazole and lemborexant
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names lemborexant in its drug interactions section, and lemborexant's label names fluconazole too. The lemborexant label: “Concomitant use with a strong, moderate, or weak CYP3A inhibitor increases lemborexant AUC and C max which may increase the risk of DAYVIGO adverse reactions.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the lemborexant FDA label on DailyMed (effective February 24, 2025, Eisai Inc.).
What does the fluconazole label say about lemborexant?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsLemborexant Concomitant administration of fluconazole increased lemborexant C max and AUC by approximately 1.6-and 4.2-fold, respectively which is expected to increase risk of adverse reactions, such as somnolence.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the lemborexant label say about fluconazole?
Lemborexant label, drug interactionsStrong, Moderate, and Weak CYP3A Inhibitors Clinical Impact: Concomitant use with a strong, moderate, or weak CYP3A inhibitor increases lemborexant AUC and C max which may increase the risk of DAYVIGO adverse reactions. … Administration ()]. Examples: Strong CYP3A inhibitors: itraconazole, clarithromycin Moderate CYP3A inhibitors: fluconazole, verapamil Weak CYP3A inhibitors: chlorzoxazone, ranitidine
Source: FDA drug label (DAYVIGO), Eisai Inc., effective February 24, 2025 (SPL set 7074cb65-77b3-45d2-8e8d-da8dc0f70bfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Lemborexant | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Insomnia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $11.57 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once