What the FDA labels say about taking them together
Fexinidazole and metronidazole
Fexinidazole's FDA label of May 2, 2025 names metronidazole in its contraindications section; the metronidazole labels PlainMeds reads (4) do not name fexinidazole. The fexinidazole label: “CONTRAINDICATIONS Fexinidazole Tablets are contraindicated in: Patients with known hypersensitivity to Fexinidazole Tablets and/or any nitroimidazole-class drugs.”
Check it at the source: the fexinidazole FDA label on DailyMed (effective May 2, 2025, Sanofi-Aventis U.S. LLC); the metronidazole FDA label on DailyMed (effective September 3, 2024, Aurobindo Pharma Limited).
What does the fexinidazole label say about metronidazole?
Fexinidazole label, contraindicationsCONTRAINDICATIONS Fexinidazole Tablets are contraindicated in: Patients with known hypersensitivity to Fexinidazole Tablets and/or any nitroimidazole-class drugs (e.g., metronidazole, tinidazole).
Source: FDA drug label (Fexinidazole), Sanofi-Aventis U.S. LLC, effective May 2, 2025 (SPL set 74a611bc-9977-46bb-b626-0370b3031628), via openFDA; the full label on DailyMed
What does the metronidazole label say about fexinidazole?
Metronidazole's label (effective September 3, 2024) and its 3 other brand-application labels do not name fexinidazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Metronidazole), Aurobindo Pharma Limited, effective September 3, 2024 (SPL set f68397ee-67db-472e-8607-4300064e37df), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fexinidazole | Metronidazole | |
|---|---|---|
| Labeled for | n/a | Bacterial infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.102 per tablet 250 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once