What the FDA labels say about taking them together
Etravirine and nelfinavir
Etravirine's FDA label of August 15, 2023 names nelfinavir in its drug interactions section; the nelfinavir label PlainMeds reads does not name etravirine. The etravirine label: “Concomitant use of INTELENCE with nelfinavir without low-dose ritonavir may cause a significant alteration in the plasma concentration of nelfinavir. …”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON).
What does the etravirine label say about nelfinavir?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: nelfinavir (without ritonavir); Effect on Concentration of Etravirine or Concomitant Drug: ↑ nelfinavir; Clinical Comment: Concomitant use of INTELENCE with nelfinavir without low-dose ritonavir may cause a significant alteration in the plasma concentration of nelfinavir. Co-administration of INTELENCE and nelfinavir without low-dose ritonavir is not recommended.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the nelfinavir label say about etravirine?
Nelfinavir's label (effective December 11, 2025) does not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Nelfinavir | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once