What the FDA labels say about taking them together
Etonogestrel and nelfinavir
Etonogestrel's FDA label of May 28, 2026 names nelfinavir in its drug interactions section; the nelfinavir label PlainMeds reads does not name etonogestrel. The etonogestrel label: “Significant changes (increase or decrease) in the plasma concentrations of progestin have been noted in cases of co-administration with HIV protease inhibitors or with non-nucleoside reverse transcriptase inhibitors.”
Check it at the source: the etonogestrel FDA label on DailyMed (effective May 28, 2026, Organon LLC); the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON).
What does the etonogestrel label say about nelfinavir?
Etonogestrel label, drug interactionsSignificant changes (increase or decrease) in the plasma concentrations of progestin have been noted in cases of co-administration with HIV protease inhibitors (decrease [e.g., nelfinavir] or increase [e.g., indinavir, ritonavir and ritonavir-boosted protease inhibitors]) or with non-nucleoside reverse transcriptase inhibitors (decrease [e.g., nevirapine, efavirenz] or increase [e.g., etravirine]).
Source: FDA drug label (Nexplanon), Organon LLC, effective May 28, 2026 (SPL set 487f8a62-e142-457c-97cc-2e398fde7594), via openFDA; the full label on DailyMed
What does the nelfinavir label say about etonogestrel?
Nelfinavir's label (effective December 11, 2025) does not name etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etonogestrel | Nelfinavir | |
|---|---|---|
| Labeled for | Birth control | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once