What the FDA labels say about taking them together
Ethinyl estradiol/segesterone and nelfinavir
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names nelfinavir in its drug interactions section; the nelfinavir label PlainMeds reads does not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “Significant decreases in systemic exposure of estrogen and/or progestin have been noted when CHCs are co-administered with some HIV protease inhibitors, some HCV protease inhibitors, and some non-nucleoside reverse …”
Check it at the source: the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025); the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON).
What does the ethinyl estradiol/segesterone label say about nelfinavir?
Ethinyl estradiol/segesterone label, drug interactionsSignificant decreases in systemic exposure of estrogen and/or progestin have been noted when CHCs are co-administered with some HIV protease inhibitors (eg, nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir), some HCV protease inhibitors (eg, boceprevir and telaprevir), and some non-nucleoside reverse transcriptase inhibitors (eg, nevirapine).
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
What does the nelfinavir label say about ethinyl estradiol/segesterone?
Nelfinavir's label (effective December 11, 2025) does not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/segesterone | Nelfinavir | |
|---|---|---|
| Labeled for | Birth control | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2,315.29 per ring Annovera vaginal ring | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once