What the FDA labels say about taking them together
Eszopiclone and olanzapine
Eszopiclone's FDA label of January 30, 2026 names olanzapine in its drug interactions section; the olanzapine labels PlainMeds reads (3) do not name eszopiclone. The eszopiclone label: “Coadministration of eszopiclone and olanzapine produced a decrease in DSST scores.”
Check it at the source: the eszopiclone FDA label on DailyMed (effective January 30, 2026, Glenmark Pharmaceuticals Inc. USA); the olanzapine FDA label on DailyMed (effective March 5, 2026, Macleods Pharmaceuticals Limited).
What does the eszopiclone label say about olanzapine?
Eszopiclone label, drug interactionsCoadministration of eszopiclone and olanzapine produced a decrease in DSST scores.
Source: FDA drug label (Eszopiclone), Glenmark Pharmaceuticals Inc. USA, effective January 30, 2026 (SPL set 584dc66c-063a-4552-a056-74b811e2bc80), via openFDA; the full label on DailyMed
What does the olanzapine label say about eszopiclone?
Olanzapine's label (effective March 5, 2026) and its 2 other brand-application labels do not name eszopiclone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Olanzapine), Macleods Pharmaceuticals Limited, effective March 5, 2026 (SPL set 8e095987-bdea-42f2-9550-c7155cf07d30), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eszopiclone | Olanzapine | |
|---|---|---|
| Labeled for | Insomnia | Schizophrenia, Bipolar disorder, Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0993 per tablet 1 mg tablet | $0.147 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once