What the FDA labels say about taking them together
Esomeprazole and lapatinib ditosylate
Lapatinib ditosylate's FDA label of November 30, 2023 names esomeprazole in its drug interactions section; the esomeprazole labels PlainMeds reads (3) do not name lapatinib ditosylate. The lapatinib ditosylate label: “However, esomeprazole, a proton pump inhibitor, administered at a dose of 40 mg once daily for 7 days, did not result in a clinically meaningful reduction in lapatinib steady-state exposure.”
Check it at the source: the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC); the lapatinib ditosylate FDA label on DailyMed (effective November 30, 2023, Teva Pharmaceuticals, Inc.).
What does the esomeprazole label say about lapatinib ditosylate?
Esomeprazole's label (effective March 19, 2024) and its 2 other brand-application labels do not name lapatinib ditosylate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
What does the lapatinib ditosylate label say about esomeprazole?
Lapatinib ditosylate label, drug interactionsHowever, esomeprazole, a proton pump inhibitor, administered at a dose of 40 mg once daily for 7 days, did not result in a clinically meaningful reduction in lapatinib steady-state exposure.
Source: FDA drug label (Lapatinib), Teva Pharmaceuticals, Inc., effective November 30, 2023 (SPL set b09abf73-1eef-4e12-b400-c030d546d223), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Esomeprazole | Lapatinib ditosylate | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Breast cancer |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.145 per capsule 20 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once