What the FDA labels say about taking them together
Eslicarbazepine and phenytoin
Eslicarbazepine's FDA label of November 10, 2023 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name eslicarbazepine. The eslicarbazepine label: “Higher dosage of APTIOM may be necessary and dose adjustment may be needed for phenytoin. Phenobarbital or Primidone:”
Check it at the source: the eslicarbazepine FDA label on DailyMed (effective November 10, 2023, Sumitomo Pharma America, Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the eslicarbazepine label say about phenytoin?
Eslicarbazepine label, drug interactionsHigher dosage of APTIOM may be necessary and dose adjustment may be needed for phenytoin. ( 2.3 , 7.1 , 7.2 ) Phenobarbital or Primidone:
Source: FDA drug label (Aptiom), Sumitomo Pharma America, Inc., effective November 10, 2023 (SPL set 3d0c9554-eaeb-4694-8089-00133fcadce3), via openFDA; the full label on DailyMed
What does the phenytoin label say about eslicarbazepine?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name eslicarbazepine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eslicarbazepine | Phenytoin | |
|---|---|---|
| Labeled for | Seizures and epilepsy | Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.68 per tablet 200 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once