What the FDA labels say about taking them together
Ertapenem and probenecid
Ertapenem's FDA label of February 4, 2026 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name ertapenem. The ertapenem label: “DRUG INTERACTIONS Co-administration with probenecid inhibits the renal excretion of ertapenem and is therefore not recommended. The concomitant use of ertapenem and valproic acid/divalproex sodium is generally not …”
Check it at the source: the ertapenem FDA label on DailyMed (effective February 4, 2026, Merck Sharp & Dohme LLC); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the ertapenem label say about probenecid?
Ertapenem label, drug interactionsDRUG INTERACTIONS Co-administration with probenecid inhibits the renal excretion of ertapenem and is therefore not recommended. ( 7.1 ) The concomitant use of ertapenem and valproic acid/divalproex sodium is generally not recommended.
Source: FDA drug label (INVANZ), Merck Sharp & Dohme LLC, effective February 4, 2026 (SPL set 33f3b99b-fa82-42e0-26bf-f49891ae3d22), via openFDA; the full label on DailyMed
What does the probenecid label say about ertapenem?
Probenecid's label (effective January 5, 2021) does not name ertapenem in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ertapenem | Probenecid | |
|---|---|---|
| Labeled for | Urinary tract infections | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $26.63 per vial 1 gram vial | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once