What the FDA labels say about taking them together
Epoprostenol and furosemide
Epoprostenol's FDA label of November 28, 2022 names furosemide in its drug interactions section; the furosemide labels PlainMeds reads (4) do not name epoprostenol. The epoprostenol label: “In a pharmacokinetic substudy in patients with congestive heart failure receiving furosemide or digoxin in whom therapy with epoprostenol was initiated, apparent oral clearance values for furosemide (n=23) and digoxin …”
Check it at the source: the epoprostenol FDA label on DailyMed (effective November 28, 2022, Actelion Pharmaceuticals US, Inc.); the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC).
What does the epoprostenol label say about furosemide?
Epoprostenol label, drug interactionsIn a pharmacokinetic substudy in patients with congestive heart failure receiving furosemide or digoxin in whom therapy with epoprostenol was initiated, apparent oral clearance values for furosemide (n=23) and digoxin (n=30) were decreased by 13% and 15%, respectively, on the second day of therapy and had returned to baseline values by day 87.
Source: FDA drug label (Veletri), Actelion Pharmaceuticals US, Inc., effective November 28, 2022 (SPL set df502787-46ec-4dd1-a2c0-be90f6d95a5d), via openFDA; the full label on DailyMed
What does the furosemide label say about epoprostenol?
Furosemide's label (effective September 30, 2025) and its 3 other brand-application labels do not name epoprostenol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epoprostenol | Furosemide | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.490 per mL 20 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once