What the FDA labels say about taking them together
Eplerenone and spironolactone
Eplerenone's FDA label of June 23, 2025 names spironolactone in its contraindications section, and spironolactone's label names eplerenone too. The spironolactone label: “Hyperkalemia Addison’s disease Concomitant use of eplerenone Spironolactone oral suspension is contraindicated in patients with:”
Check it at the source: the eplerenone FDA label on DailyMed (effective June 23, 2025, Viatris Specialty LLC); the spironolactone FDA label on DailyMed (effective November 28, 2025, Pfizer Laboratories Div Pfizer Inc).
What does the eplerenone label say about spironolactone?
Eplerenone label, contraindicationsconcomitant administration of potassium supplements or potassium-sparing diuretics (e.g., amiloride, spironolactone, or triamterene) [see Warnings and Precautions (5.1), Adverse Reactions (6.2), Drug Interactions (7), and Clinical Pharmacology (12.3) ].
Source: FDA drug label (Inspra), NDA021437 (Upjohn), as published by Viatris Specialty LLC, effective June 23, 2025 (SPL set 1a52bedc-8e2c-4116-a296-a87770676b4a), via openFDA; the full label on DailyMed
What does the spironolactone label say about eplerenone?
Spironolactone label, contraindicationsConcomitant use of eplerenone ALDACTONE is contraindicated in patients with ( 4 ): ▪ Hyperkalemia ▪ Addison's disease ▪ Concomitant use of eplerenone
Spironolactone label (Atlantic Biologicals Corp., August 28, 2026), contraindicationsHyperkalemia Addison’s disease Concomitant use of eplerenone Spironolactone oral suspension is contraindicated in patients with ( 4 ):
Source: FDA drug label (Spironolactone, NDA209478), Atlantic Biologicals Corp., effective August 28, 2026 (SPL set 5a203ae4-0ed1-0099-e063-6294a90abc85), via openFDA
Source: FDA drug label (Aldactone), Pfizer Laboratories Div Pfizer Inc, effective November 28, 2025 (SPL set 0fed2822-3a03-4b64-9857-c682fcd462bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eplerenone | Spironolactone | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | Heart failure, Edema (fluid retention), High blood pressure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.308 per tablet 25 mg tablet | $0.0426 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once