What the FDA labels say about taking them together
Epinephrine and timolol
Timolol's FDA label of June 27, 2025 names epinephrine in its drug interactions section; epinephrine's label does not name timolol itself but warns about its class (Beta blockers).
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the timolol FDA label on DailyMed (effective June 27, 2025, Thea Pharma Inc.).
What does the epinephrine label say about timolol?
Epinephrine's label does not name timolol itself; it warns about its class (Beta blockers):
Epinephrine label, drug interactionsDRUG INTERACTIONS Drugs that counter the pressor effects of epinephrine include alpha blockers, vasodilators such as nitrates, diuretics, antihypertensives, and ergot alkaloids. ( 7 .1) Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. …
Epinephrine label, drug interactionsAntidepressants, Monoamine Oxidase Inhibitors, Levothyroxine, and Antihistamines The effects of epinephrine may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine. Beta-Adrenergic Blockers The cardiostimulating and bronchodilating effects of epinephrine are antagonized by beta- adrenergic blocking drugs, such as propranolol.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the timolol label say about epinephrine?
Timolol label, drug interactionsInjectable Epinephrine (See PRECAUTIONS, General, Anaphylaxis .)
Timolol Maleate label (Bausch & Lomb Americas Inc., November 4, 2024), warnings and precautionsSuch patients may be unresponsive to the usual doses of epinephrine used to treat anaphylactic reactions.
Timolol Maleate label (Bausch & Lomb Americas Inc., March 4, 2025), drug interactionsDrug Interactions Although Timolol Maleate Ophthalmic Solution used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with Timolol Maleate Ophthalmic Solution and epinephrine has been reported occasionally.
Source: FDA drug label (Timolol Maleate, NDA021516), Bausch & Lomb Americas Inc., effective November 4, 2024 (SPL set b686bbad-1ef7-4b94-a316-4d182a40b89a), via openFDA
Source: FDA drug label (Timolol Maleate, NDA018086), Bausch & Lomb Americas Inc., effective March 4, 2025 (SPL set 9c14ca2d-80f3-48ef-b99a-beafaa728a24), via openFDA
Source: FDA drug label (BETIMOL), Thea Pharma Inc., effective June 27, 2025 (SPL set 3ae775f4-340c-4bf4-aa49-8a31daba0f8b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Timolol | |
|---|---|---|
| Labeled for | Asthma | Glaucoma, High blood pressure, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $0.774 per mL 0.5% eye drops |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once