What the FDA labels say about taking them together
Epinephrine and protriptyline
Protriptyline's FDA label of July 25, 2023 names epinephrine in its drug interactions section; epinephrine's label does not name protriptyline itself but warns about its class (Tricyclic antidepressants). The protriptyline label: “Drug Interactions When protriptyline is given with anticholinergic agents or sympathomimetic drugs, including epinephrine combined with local anesthetics, close supervision and careful adjustment of dosages are required.”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the protriptyline FDA label on DailyMed (effective July 25, 2023, Epic Pharma, LLC).
What does the epinephrine label say about protriptyline?
Epinephrine's label does not name protriptyline itself; it warns about its class (Tricyclic antidepressants):
Epinephrine label, drug interactionsDRUG INTERACTIONS Drugs that counter the pressor effects of epinephrine include alpha blockers, vasodilators such as nitrates, diuretics, antihypertensives, and ergot alkaloids. ( 7 .1) Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. …
Epinephrine label, drug interactionsAntidepressants, Monoamine Oxidase Inhibitors, Levothyroxine, and Antihistamines The effects of epinephrine may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the protriptyline label say about epinephrine?
Protriptyline label, drug interactionsDrug Interactions When protriptyline is given with anticholinergic agents or sympathomimetic drugs, including epinephrine combined with local anesthetics, close supervision and careful adjustment of dosages are required.
Source: FDA drug label (Protriptyline Hydrochloride), Epic Pharma, LLC, effective July 25, 2023 (SPL set c6c7c39e-e510-4f4a-bf7a-926f0e075d3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Protriptyline | |
|---|---|---|
| Labeled for | Asthma | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $2.71 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once