What the FDA labels say about taking them together
Enzalutamide and warfarin
Enzalutamide's FDA label (Xtandi) of May 25, 2021 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name enzalutamide. The enzalutamide label: “If XTANDI is co-administered with warfarin (CYP2C9 substrate), conduct additional INR monitoring.”
Check it at the source: the enzalutamide FDA label on DailyMed (effective July 28, 2026, Astellas Pharma US, Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the enzalutamide label say about warfarin?
Xtandi label (Astellas Pharma US, Inc., May 25, 2021), drug interactionsIf XTANDI is co-administered with warfarin (CYP2C9 substrate), conduct additional INR monitoring.
Source: FDA drug label (Xtandi, NDA213674), Astellas Pharma US, Inc., effective May 25, 2021 (SPL set 381cd215-78c9-4208-8595-7ae7a279b236), via openFDA
Source: FDA drug label (Xtandi), Astellas Pharma US, Inc., effective July 28, 2026 (SPL set b129fdc9-1d8e-425c-a5a9-8a2ed36dfbdf), via openFDA; the full label on DailyMed
What does the warfarin label say about enzalutamide?
Warfarin's label (effective May 29, 2026) does not name enzalutamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Enzalutamide | Warfarin | |
|---|---|---|
| Labeled for | Prostate cancer | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once