What the FDA labels say about taking them together
Enalapril and tenapanor
Tenapanor's FDA label of June 27, 2025 names enalapril in its drug interactions section; the enalapril labels PlainMeds reads (2) do not name tenapanor. The tenapanor label: “DRUG INTERACTIONS OATP2B1 Substrates: Potential for reduced exposure of the concomitant drug (e.g., enalapril).”
Check it at the source: the enalapril FDA label on DailyMed (effective January 23, 2026, Bausch Health US LLC); the tenapanor FDA label on DailyMed (effective June 27, 2025, Ardelyx, Inc.).
What does the enalapril label say about tenapanor?
Enalapril's label (effective January 23, 2026) and its 1 other brand-application label do not name tenapanor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Vasotec), Bausch Health US LLC, effective January 23, 2026 (SPL set 39631f1f-5d19-43c1-b504-bf56d991ed97), via openFDA; the full label on DailyMed
What does the tenapanor label say about enalapril?
Tenapanor label, drug interactionsDRUG INTERACTIONS OATP2B1 Substrates: Potential for reduced exposure of the concomitant drug (e.g., enalapril).
Source: FDA drug label (XPHOZAH 10 mg), Ardelyx, Inc., effective June 27, 2025 (SPL set c57e279c-0f1b-4238-81b7-4e0dc0cc60c5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Enalapril | Tenapanor | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure | Irritable bowel syndrome, Constipation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0664 per tablet 10 mg tablet | $32.54 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once