What the FDA labels say about taking them together
Enalapril and sulindac
Enalapril's FDA label of January 23, 2026 names sulindac in its drug interactions section; sulindac's label does not name enalapril itself but warns about its class (ACE inhibitors).
Check it at the source: the enalapril FDA label on DailyMed (effective January 23, 2026, Bausch Health US LLC); the sulindac FDA label on DailyMed (effective December 20, 2024, Epic Pharma, LLC).
What does the enalapril label say about sulindac?
Enalapril label, drug interactionsIn a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving VASOTEC.
Source: FDA drug label (Epaned, NDA208686), Azurity Pharmaceuticals, Inc., effective December 16, 2025 (SPL set e6dbda02-779e-420c-893d-d0fea09432be), via openFDA
Source: FDA drug label (Vasotec), Bausch Health US LLC, effective January 23, 2026 (SPL set 39631f1f-5d19-43c1-b504-bf56d991ed97), via openFDA; the full label on DailyMed
What does the sulindac label say about enalapril?
Sulindac's label does not name enalapril itself; it warns about its class (ACE inhibitors):
Sulindac label, warningsPatients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, patients who are volume-depleted, and the elderly.
Source: FDA drug label (SULINDAC), Epic Pharma, LLC, effective December 20, 2024 (SPL set 96c73bd2-4577-487d-a642-bd8f91e94c3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Enalapril | Sulindac | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0664 per tablet 10 mg tablet | $0.189 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once